1 © 2015 Pearson Education, Inc.

2 Respiratory System Organs included: Nose Pharynx Larynx TracheaBronchi Lungs and alveoli

3 Nasal cavity Oral cavity Nostril Pharynx Larynx Trachea Left main (primary) bronchus Right main (primary) bronchus Left lung Right lung Diaphragm Figure 13.1

4 Functions of the Respiratory SystemGas exchanges between the blood and external environment Occurs in the alveoli of the lungs Passageways to the lungs purify, humidify, and warm the incoming air

5 The Nose Only externally visible part of the respiratory systemAir enters the nose through the external nostrils (nares) Interior of the nose consists of a nasal cavity divided by a nasal septum

6 Anatomy of the Nasal CavityOlfactory receptors are located in the mucosa on the superior surface The rest of the cavity is lined with respiratory mucosa that Moisten air Trap incoming foreign particles

7 Paranasal Sinuses Cavities within bones surrounding the nasal cavity are called sinuses Function of the sinuses Lighten the skull Act as resonance chambers for speech Produce mucus that drains into the nasal cavity

8 Cribriform plate of ethmoid bone Sphenoidal sinus Frontal sinus Posterior nasal aperture Nasal cavity Nasal conchae (superior, middle and inferior) Nasopharynx Pharyngeal tonsil Nasal meatuses (superior, middle, and inferior) Opening of pharyngotympanic tube Nasal vestibule Uvula Nostril Oropharynx Hard palate Palatine tonsil Soft palate Tongue Lingual tonsil Laryngopharynx Hyoid bone Larynx Epiglottis Esophagus Thyroid cartilage Trachea Vocal fold Cricoid cartilage (b) Detailed anatomy of the upper respiratory tract Figure 13.2b

9 Pharynx (Throat) Muscular passage from nasal cavity to larynxThree regions of the pharynx Nasopharynx—superior region behind nasal cavity Oropharynx—middle region behind mouth Laryngopharynx—inferior region attached to larynx The oropharynx and laryngopharynx are common passageways for air and food

10 (a) Regions of the pharynxNasopharynx Oropharynx Laryngopharynx (a) Regions of the pharynx Figure 13.2a

11 Larynx (Voice Box) Routes air and food into proper channelsPlays a role in speech Made of eight rigid hyaline cartilages and a spoon-shaped flap of elastic cartilage (epiglottis)

12 Structures of the LarynxThyroid cartilage Largest of the hyaline cartilages Protrudes anteriorly (Adam’s apple) Epiglottis Protects the superior opening of the larynx Routes food to the esophagus and air toward the trachea When swallowing, the epiglottis rises and forms a lid over the opening of the larynx

13 Structures of the LarynxVocal folds (true vocal cords) Vibrate with expelled air to create sound (speech) Glottis  opening between vocal cords

14 Trachea (Windpipe) Four-inch-long tube that connects larynx with bronchi Walls are reinforced with C-shaped hyaline cartilage Lined with ciliated mucosa Beat continuously in the opposite direction of incoming air Expel mucus loaded with dust and other debris away from lungs

15 Posterior Mucosa Esophagus Submucosa Trachealis Seromucous Lumen ofmuscle Lumen of trachea Seromucous gland in submucosa Hyaline cartilage Adventitia Anterior Figure 13.3a

16 Main (Primary) BronchiFormed by division of the trachea Enters the lung at the hilum (medial depression) Right bronchus is wider, shorter, and straighter than left Bronchi subdivide into smaller and smaller branches

17 Heart (in mediastinum)Posterior Vertebra Esophagus (in posterior mediastinum) Root of lung at hilum Right lung Left main bronchus Left pulmonary artery Parietal pleura Left pulmonary vein Visceral pleura Left lung Pleural cavity Thoracic wall Pulmonary trunk Pericardial membranes Heart (in mediastinum) Anterior mediastinum Sternum Anterior (b) Transverse section through the thorax, viewed from above. Lungs, pleural membranes, and major organs in the mediastinum are shown. Figure 13.4b

18 Lungs Occupy most of the thoracic cavityHeart occupies central portion called mediastinum Apex is near the clavicle (superior portion) Base rests on the diaphragm (inferior portion) Each lung is divided into lobes by fissures Left lung—two lobes Right lung—three lobes

19 (in pericardial cavity of mediastinum)Intercostal muscle Rib Parietal pleura Lung Pleural cavity Trachea Visceral pleura Thymus Apex of lung Left superior lobe Right superior lobe Oblique fissure Horizontal fissure Right middle lobe Left inferior lobe Oblique fissure Right inferior lobe Heart (in pericardial cavity of mediastinum) Diaphragm Base of lung (a) Anterior view. The lungs flank mediastinal structures laterally. Figure 13.4a

20 Respiratory Zone Structures Respiratory bronchioles Alveolar ductsAlveolar sacs Alveoli (air sacs) Site of gas exchange = alveoli only

21 Respiratory bronchioles Alveolar ductAlveoli Respiratory bronchioles Alveolar duct Terminal bronchiole Alveolar sac (a) Diagrammatic view of respiratory bronchioles, alveolar ducts, and alveoli Alveolar pores Alveolar duct Alveolus Figure 13.5a

22 Figure 13.5b

23 Gas Exchange Gas crosses the respiratory membrane by diffusionOxygen enters the blood Carbon dioxide enters the alveoli Alveolar macrophages (“dust cells”) add protection by picking up bacteria, carbon particles, and other debris Surfactant (a lipid molecule) coats gas-exposed alveolar surfaces

24 Four Events of RespirationPulmonary ventilation  moving air in and out of the lungs (commonly called breathing) External respiration  gas exchange between pulmonary blood and alveoli Oxygen is loaded into the blood Carbon dioxide is unloaded from the blood

25 O2 CO2 CO2 Red blood cell Endothelial cell nucleus CapillaryAlveolar pores O2 Capillary O2 CO2 CO2 Macrophage Alveolus Nucleus of squamous epithelial cell Respiratory membrane Alveolar epithelium Fused basement membranes Capillary endothelium Figure 13.6 (2 of 2)

26 Four Events of RespirationRespiratory gas transport  transport of oxygen and carbon dioxide via the bloodstream Internal respiration  gas exchange between blood and tissue cells in systemic capillaries

27 Mechanics of Breathing (Pulmonary Ventilation)Two phases Inspiration = inhalation Flow of air into lungs Expiration = exhalation Air leaving lungs

28 Inspiration Diaphragm and external intercostal muscles contractThe size of the thoracic cavity increases External air is pulled into the lungs due to Increase in intrapulmonary volume Decrease in gas pressure

29 intercostals contract)Changes in anterior-posterior and superior-inferior dimensions Changes in lateral dimensions Ribs elevated as external intercostals contract Full inspiration (External intercostals contract) External intercostal muscles Diaphragm moves inferiorly during contraction (a) Inspiration: Air (gases) flows into the lungs Figure 13.7a

30 Expiration Largely a passive process which depends on natural lung elasticity As muscles relax, air is pushed out of the lungs due to Decrease in intrapulmonary volume Increase in gas pressure Forced expiration can occur mostly by contracting internal intercostal muscles to depress the rib cage

31 Expiration (External intercostals relax)Changes in anterior-posterior and superior-inferior dimensions Changes in lateral dimensions Ribs depressed as external intercostals relax Expiration (External intercostals relax) External intercostal muscles Diaphragm moves superiorly as it relaxes (b) Expiration: Air (gases) flows out of the lungs Figure 13.7b

32 V 𝑶 𝟐 Max V 𝑂 2 Max The maximum rate of oxygen consumption as measured during incremental exercise Reflection of the overall aerobic physical fitness of an individual Important determinant in endurance capacity during prolonged, submaximal exercise

33

34 Homeostatic ImbalanceAtelectasis Lung collapse The lung is useless for ventilation Seen when air enters the pleural space through a chest wound, but can also result from a rupture of the visceral pleura

35 Nonrespiratory Air (Gas) MovementsCan be caused by reflexes or voluntary actions Examples: Cough and sneeze—clears lungs of debris Crying—emotionally induced mechanism Laughing—similar to crying Hiccup—sudden inspirations Yawn—very deep inspiration

36 Respiratory Volumes and CapacitiesResidual volume Air remaining in lung after expiration About 1200 mL

37 External Respiration Oxygen loaded into the bloodThe alveoli always have more oxygen than the blood Oxygen moves by diffusion towards the area of lower concentration Pulmonary capillary blood gains oxygen

38 External Respiration Carbon dioxide unloaded out of the bloodBlood returning from tissues has higher concentrations of carbon dioxide than air in the alveoli Pulmonary capillary blood gives up carbon dioxide to be exhaled Blood leaving the lungs is oxygen-rich and carbon dioxide-poor

39 Oxygen is loaded into the blood and carbon dioxide is unloaded.(a) External respiration in the lungs (pulmonary gas exchange) Oxygen is loaded into the blood and carbon dioxide is unloaded. Alveoli (air sacs) O2 CO2 Loading of O2 Unloading of CO2 Hb + O HbO2 HCO3_ + H H2CO CO2+ H2O (Oxyhemoglobin is formed) Bicar- bonate ion Carbonic acid Water Plasma Red blood cell Pulmonary capillary Figure 13.11a

40 Internal Respiration Exchange of gases between blood and body cellsAn opposite reaction to what occurs in the lungs Carbon dioxide diffuses out of tissue to blood (called loading) Oxygen diffuses from blood into tissue (called unloading)

41 Oxygen is unloaded and carbon dioxide is loaded into the blood.(b) Internal respiration in the body tissues (systemic capillary gas exchange) Oxygen is unloaded and carbon dioxide is loaded into the blood. Tissue cells CO2 O2 Loading of CO2 Unloading of O2 CO2+ H2O H2CO H++ HCO3_ Water Carbonic acid Bicar- bonate ion HbO Hb + O2 Plasma Systemic capillary Red blood cell Figure 13.11b

42 Neural Regulation of RespirationNormal respiratory rate (eupnea) 12 to 15 respirations per minute Hyperpnea Increased respiratory rate often due to extra oxygen needs

43 Hyperventilation and HypoventilationResults from increased CO2 in the blood (acidosis) Breathing becomes deeper and more rapid Blows off more CO2 to restore normal blood pH

44 Hyperventilation and HypoventilationResults when blood becomes alkaline (alkalosis) Extremely slow or shallow breathing Allows CO2 to accumulate in the blood

45 Homeostatic ImbalanceApnea Cessation (stopping) of breathing Usually brought on by hyperventilation as a result of an anxiety attack Decreases the amount of 𝐶𝑂 2 , in the blood so breathing is stopped until normal levels can build back up in the blood

46 Respiratory Disorders: Chronic Obstructive Pulmonary Disease (COPD)Exemplified by chronic bronchitis and emphysema Major causes of death and disability in the United States

47 Respiratory Disorders: Chronic Obstructive Pulmonary Disease (COPD)Features of these diseases Patients almost always have a history of smoking Labored breathing (dyspnea) becomes progressively more severe Coughing and frequent pulmonary infections are common

48 Respiratory Disorders: Chronic BronchitisMucosa of the lower respiratory passages becomes severely inflamed Mucus production increases Pooled mucus impairs ventilation and gas exchange Risk of lung infection increases Pneumonia is common Called “blue bloaters” due to hypoxia and cyanosis

49 Respiratory Disorders: EmphysemaAlveoli enlarge as adjacent chambers break through Chronic inflammation promotes lung fibrosis Airways collapse during expiration Patients use a large amount of energy to exhale Overinflation of the lungs leads to a permanently expanded barrel chest Cyanosis appears late in the disease; sufferers are often called “pink puffers”

50 Figure 13.13

51 Lung Cancer Accounts for one-third of all cancer deaths in the United States Increased incidence is associated with smoking Three common types Squamous cell carcinoma Adenocarcinoma Small cell carcinoma

52 Developmental Aspects of the Respiratory SystemSudden Infant Death Syndrome (SIDS) Apparently healthy infant stops breathing and dies during sleep Some cases are thought to be a problem of the neural respiratory control center One third of cases appear to be due to heart rhythm abnormalities Recent research shows a genetic component