1 Artificial Intelligence in MedicineThirty years of AIME conferences (1985 – 2015)

2 AIME biennial conferences1985 Pavia, Italy 1987 Marseille, France 1989 London, UK 1991 Maastricht, The Netherlands 1993 Munich, Germany 1995 Pavia, Italy 1997 Grenoble, France 1999 Aalborg, Denmark 2001 Cascais, Portugal 2003 Protaras, Cyprus 2005 Aberdeen, UK 2007 Amsterdam, The Netherlands 2009 Verona, Italy 2011 Bled, Slovenia 2013 Murcia, Spain 2015 Pavia, Italy

3 Research Topics Knowledge engineering 25%Ontologies and terminologies 11% Natural language processing 8% Guidelines and protocols 10% Temporal information management 9% Planning and scheduling 3% Case based reasoning 3% Distributed and cooperative systems 4% Uncertainty management 10% Machine learning, data mining 26% Image and signal processing 8% Bioinformatics 3%

4 Temporal Information ManagementTemporal abstraction Time series data Clinical pathway analysis

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7 Temporal Information Management (1)Kahn MG, In pursuit of time’s arrow: Temporal reasoning in medical decision support Shahar Y, Timing is everything: Temporal reasoning and temporal data maintenance in medicine Keravnou ET, Modelling medical concepts as time-objects Chittaro L, Del Rosso M, Dojat M, Modeling medical reasoning with the event calculus: An application to the management of mechanical ventilation Larizza C, Bernuzzi G, Stefanelli M, A general framework for building patient monitoring systems Spyropoulos CD, Kokkotos S, Marinagi C, Planning and scheduling patient tests in hospital laboratories Ramaux N, Fontaine D, Dojat M, Temporal scenario recognition for intelligent patient monitoring

8 Temporal Information Management (2)Seyfang A, Miksch S, Horn W, Urschitz MS, Popow C, Poets CF, Using time-oriented data abstraction methods to optimize oxygen supply for neonates Hunter J, Meintosh N, Knowledge-based event detection in complex time series data Miksch S, Seyfang A, Horn W, Popow C, Abstracting steady qualitative descriptions over time from noisy, high-frequency data Combi C, Portoni L, Pinciroli F, Visualizing temporal clinical data on the www Charbonnier S, On-line extraction of successive temporal sequences from ICU high-frequency data for decision support information Bellazzi R, Larizza C, Magni P, Temporal data mining for the quality assessment of hemodialysis services

9 Temporal Information Management (3)Boaz D, Shahar Y, A framework for distributed mediation of temporal-abstraction queries to clinical databases Combi C, Oliboni B, Rossato R, Modeling multimedia and temporal aspects Sharshar S, Allart L, Chambrin M-C, A new approach to the abstraction of monitoring data in intensive care Terenziani P, Snodgrass RT, Bottrighi A, Torchio M, Molino G, Extending temporal databases to deal withy telic/atelic medical data Campos M, Palma JT, Marin R, Temporal data mining with temporal constraints Concaro S, Sacchi L, Fratino P, Bellazzi R, Mining health care data with temporal association rules Gao F, Sripada Y, Hunter J and Portet F, Using temporal constraints to integrate signal analysis and domain knowledge in medical event detection

10 Temporal Information Management (4)Chausa P, Caceres C, Sacchi L, Leon A, Garcia F, Bellazzi R, Temporal data mining of HIV registries: Results from a 25 years follow-up Minne L, de Jonge E, Abu-Hanna A, Repeated prognosis in the intensive care: How well do physicians and temporal models perform? O’Connor MJ, Hernandez G, Das AK, A rule-based method for specifying and querying temporal abstractions Gonzalez-Ferrer A, ted Teije A, Fernandez-Olivares J, Milian K, Careflow planning: From time-annotated clinical guidelines to temporal hierarchical task networks Liu Z, Hauskrecht M, Clinical time series prediction with a hierarchical dynamical system Combi C, Sabaini A, Extraction, analysis and visualization of temporal association rules from interval-based clinical data Huang Z, Lu X, Duan H, Similarity measuring between patient traces for clinical pathway analysis

11 The temporal dimension is of paramount importance for the design of successful medical application of intelligent systems, and it is therefore not surprising that it has been addressed by many AIME papers over the years

12 Planning and scheduling, and machine learning and data mining have tight links with temporal information management and temporal reasoning

13 Future Directions Big data and personalized medicineElectronic Health Record (HER) systems Temporal multidimensional online analytical processing (OLAP) Temporal data warehouse design Temporal data mining and visual mining Evidence based medicine Business process modeling and process mining Temporal constraints NLP, social media and the web

14 Temporal representation and reasoning in medicine: Research directions and challenges AIME 2006 Position Paper Fuzzy logic, time, and medicine Temporal reasoning and data mining Health information systems, business processes, and time Temporal clinical databases