1 Beauty-care Section of Product Management Dept.EGF Skincare Serum 1. History of skin-care products 2. Advantages of gene beauty 3. What is EGF? Factors of skin aging Meaning of EGF EGF effect 4.characters of our prodcuts 5.Using methods and presentation 6. Sharing Beauty-care Section of Product Management Dept. 1
2 ？ The progress of modern skin-care productGeneration Ⅲ-Anti-oxidating products Vitamin C and Vitamin E are added to the products. Generation Ⅱ-Natural Extracts Natural extracts or processing products, such as aloe, algae etc Generation Ⅰ-Mineral oil products Cheap products with mineral oil compounds such as Vaseline. 2
3 the representative of fourth generationGeneration Ⅳ-Gene Regeneration Products Nourishing skin and anti-aging on the level of cells & molecules EGF the representative of fourth generation Nourishing skin and anti-aging on the level of cell & molecule 3
4 EGF- Nourishing skin and anti-aging on the level of cells & molecules EGF- Nourishing skin and anti-aging on the level of cells & molecules Epidermal Growth Factor Skincare Serum The product can complement the losing EGF in the skin timely, enhance cell activity, promote cell multiplication, accelerate the metabolism of skin cells, and extend cell life cycle, so that the skin will maintain the optimal physical condition.thus prevent skin aging, recur flexibility and ruddy skin color. It’s so wonderful!but is that true? The answer is “yes”. Epidermal Growth Factor Skincare Serum introduces EGF freeze-dry powder extracted by modern biotechnology. EGF is frozen out in vacuum state,treated by some cocooning and kept at the state of dry powder in order to maintain its’ activity and stability for long time. Once dissolved in water or other cosmetics such as cream、lotion,the activity of EGF can only maintain no more than 10 days. Based on this specific characteristic of EGF, our experts designed the one-month pack: That is : freezing-dry powder 100mg×4; menstruum 20ml×4 In order to get the best effect,we strongly suggest that one freezing-dry powder with one menstruum, should be used out in one week. Up to now, you may ask me: What’s EGF? Why is it so mirable? Let me tell you the secret of EGF. . 4
5 Nobel Prize in Physiology and Medicine in 1986The discovery of EGF EGF is the abbreviation of Epidermal Growth Factor, which is an inherent active substance in human body. In 1962, Doctor Kohen found EGF during an experiment occasionally, which is a kind of micro molecule polypeptide widely exists inside human’s body and other animals, with trace quantities it can strongly stimulate cell growth, inhibit the emergence of old genes, delay epidermis aging, make all organizations of skin achieving the best physical condition. In addition, it can also stimulate the synthesis and secretion of some large molecules and moisten skin, so it is the source of health and vitality. The discovery of EGF has revealed the secret of skin growth, aging and physical pathological changes, create a brand new era in the field of science research. Doctor Kohen therefore was awarded the Nobel Prize in 1986. Nobel Prize in Physiology and Medicine in 1986 Dr. Cohen 5
6 Reveals the secret inside skin !The significance of the discovery EGF opens a wide and important new field for the researching of life science. ---Nobel Prize committee Creates new era of life science and technology Makes human beings’ dream of anti-aging come true Reveals the secret inside skin ! 6
7 directly decides the real age of skinThe content of EGF directly decides the real age of skin When we are young,there is much more EGF inside our skin,and the skin is tender,clear and full of elasticity. Year by year, EGF get losing, wrinkles come up to our face and our skin turn older and older. So we can say The content of EGF directly decides the real age of skin. Why we say like this? Let’s see the causes of skin aging. 3-11 71-80 11-20 age EGFng/mg creatinine There are 3.5 to 4 billion people in the world who need EGF supplements 7
8 Skin layer Skin ditch Skin rash Horny layer Epidermis layer Oil glandSweat gland Artery Vein Muscle Our skin is composed of three layers: the epidermal layer、Dermis layer and underlayer tissue 8
9 Epidermis layer horny layer spiny layer grainy layerlight /clear layer horny cell spiny cell grainy cell a horny cell is flaking off at the epidermal layer base layer 9
10 Dermis layer Dermis layer elastin collagenHealthy structure of skin tissue Dermis layer elastin collagen newborn cell Epidermal layer In the Dermis layer, elastin and collagen play an important role in supporting skin and make skin look compact and elastic in appearance,just like the spring and sponge in the sofa. When the cell vitality turns down, the regeneration of fibroblasts slows down, its elasticity is broken, the collagen elastic fibrils become atrophic, the flabby skin and wrinkles appear. 10
11 Dermis layer Dermis layer elastin collagen Epidermal layernewborn cell Epidermal layer Skin structure of collagen lost and elastin fractured
12 Factors of skin aging Factors Internal factors Gene Ageexternal factors Pressure UVA\UVB Pollution …… Direct Results Growth factors like EGF and other hormones decrease free radicals increase DNA is damaged. Act on cells Cell vitality decreases and the speed of cell division slows down. The total amount of new cell decreases collagen, elastin and hyaluronic acid etc also decrease Appearance Dry Wrinkles big pores No luster No elasticity Pigmentation Before we start to know about EGF, let’s talk about skin aging. The appearance of aging skin-Factors of skin aging-direct results-act on cells 12
13 The cytologic reason of skin ageingTotal amount of newborn cells turn less Metabolic periods of skin cells become long the cells energy decreases Skin cells become senescent collagen, elastic decrease 13
14 What can TimePassage EGF do ?Facilitate the active transport of skin cells Make young cells are more than old cells Increase cells’ Vitality and shorten the period of cells updating Data source: 1. EGF is informational molecule 2. Promote epidermal cells and fibroblasts to divide and control apoptosis 3. Increase the cell vitality 4. Form stem cells Form stem cell group 14
15 The core principles of TimePassage EGFgrow create Senescent cells mature cells Young cells Stem cells Promote the cells to be active Reverse cells division EGF EGF young 15
16 The comparison of the skin with and without EGFWithout the effect of EGF, the growth of NIH 3T3 cells in low nutrition for two days With the effect of EGF, the growth of NIH 3T3 cells in low nutrition for two days 16
17 Three technological problemsFew resources, low production ,000 liter urine=1g Expensive in price g=2,000,000 dollar Hard to keep vitality days – 2 to 3 months
18 With a large-scale productionTimePassage EGF conquer the three problems Three technological problems Few resources, low production Expensive in price Hard to keep vitality With a large-scale production Adopt the unique, international-leading genetic engineering to transcript EGF and then to produce soup-type bacillaceae which is the same to human’s endogenous-epidermal-growth-factor. Produced by TIENS, the soup-type is the only one in the world. 18
19 Greatly reduce the production costTimePassage EGF conquer the three major problems Three technological problems Few resources, low production Expensive in price Hard to keep vitality Greatly reduce the production cost make ordinary people contact Nobel achievements. Be applicable for common people.
20 High-vitality frozen-dry powerTimePassage EGF conquer the three major problems Three technological problems Few resources, low production Expensive in price Hard to keep vitality High-vitality frozen-dry power Frozen dry power can be stored for three years. High-vitality frozen-dry powder The magic effect for skin-care of EGF totally depends on its biological vitality, and nevertheless, an EGF without vitality is the same to starch and has no effect to skin. The bio-chemical characteristic of EGF shows that: after exposing to air or dissolving, the second-grade key that decides its vitality is split by oxidizing and the molecular structure changed. It will lose vitality in short time and then lose effectiveness. 1. The vitality is hard to keep in liquid; 2. The vitality of frozen-dry powder can be kept for three years; how to make frozen-dry powder? 3. After dissolving, the frozen-dry powder should be used within a week; 4. Trans-dermal absorption and usage? 20
21 21 Anti-ageing Moisturize the skin Improve broken capillariesRecover elasticity Ruddy complexion Enhance resistant ability Recover the damaged skin 21
22 Four characteristics High purity, high vitality, high stability, safe and reliable 100% homologies: Adopt human’s EGF which is extracted by modern biological engineering, and is made by gene engineering through extracting, vacuum freeze-drying and sealing. Its EGF amino acid sequence is the same to human body Do not contain any chemical ingredients, no addiction. It is safe and reliable for long use TIENS vitality-turn back the time—EGF epidermal growth factor lotion is high-tech biological products. Adopting human’s EGF which is extracted by modern biological engineering, it is made by gene engineering, extracting, vacuum freeze-drying and sealing. Its amino acid sequence is the same to human’s EGF. At all times and in all lands, no matter men and women or young and old, human’s EGF sequence is like this. Therefore, its tropism and homologies are the same as human body totally, and has no exclusiveness to human body. It can be smoothly absorbed by human body without any obstacles; and do not contain any chemical ingredients, without dependency and toxic and side effect; and it is safe and reliable for long use. Production workshop, equipment and technique of this product all reach GMP standard, and professionally produce gene beauty products. With one-off schering bottles package, the pharmaceutical-grade pollution prevention is reached: keep active by frozen-drying, high purity; no color and smell after dissolving, transparent and clean. 22
23 Production workshop, equipment andtechnique all reach GMP standard
24 Four characteristics 2. Comprehensive and fast effect
25 Example The picture is the hands of a gentleman over 73.The comparison is between His left hand and right hand. The skin condition of left hand is that used EGF for three years and then stopped using EGF lotion for three years The left picture is about a comparison between left hand and right hand. The skin condition of left hand is that used EGF lotion for three years and then stopped using EGF lotion again for three years. 25
26 Example Before using 15 days after using EGF 26
27 Example Before using 15 days after using EGF 27
28 Example 28
29 Four characteristics 3. Spraying type— convenient to useIn-bag beauty parlor
30 Four characteristics 4. High quality and low priceBeing the leading product in the newest gene beauty period, this product has the extremely technological primacy. Fundamentally solve the problem of skin aging, and it can remove wrinkles, fine skin, and recover skin elasticity at the same time; dispel the freckles and whiten skin; recover ruddy skin; improve skin hydrophilicity and nourish skin; strengthen skin resistance ability and prevent external stimulation; restore the damaged skin and accelerate wound healing etc. Therefore, it is truly high quality and low price. 30
31 Using Steps 2 1 3 4 5 With the development of times, people's living and working tempo become faster, and urban white-collar workers do not have more time in cosmetic, so that they long for a kind of convenient, safe and effective skin care products in the market. Adopting the way of spraying, this product is simple, convenient, readily available, suitable in four seasons, and even in summer, it is refreshing but not oily. Spraying it in the morning and evening, your life will be wonderful. It is really a kind of In-bag beauty parlor. 6 31
32 Morning and evening, pressing and spraying Keeps your life wonderful !32
33 Thank you !