1 En For Cé First Announcement ESE BREGENZ SUMMER SCHOOL ON ENDOCRINOLOGY Main Topics  Development of endocrine organs and tissues: Adrenals, muscle and fat cells  Activins, Inhibins, & Follistatin: endocrine and paracrine actions of the transforming growth factor-β (TGF-β) superfamily ligands  The art of trimming proteohormones: Biochemistry, structure, function and diseases  SPP ThyroidTransAct Session: Novel Thyroid hormone metabolites and non- classical mechanisms of actions  Metabolic interphases between nuclear receptors, hormones and cancer  Endocrine animal models This is a joint project of the European Society of Endocrinology (ESE) with the German Society of Endocrinology (DGE), the European Young Endocrine Scientists (EYES) & Young Active Research in Endocrinology (YARE). Sponsored by the DFG-funded Graduate College 1208 & DFG KFO 218 (Berlin) & the Bavarian Sarcopenia Network FORMOsA. The European Society of Endocrinology, the German Society of Endocrinology and DFG-funded projects can sponsor travel grants for young graduates and postgraduates. Scientific Organizing Committee: Josef Köhrle (Charité, Berlin) Franz Jakob (University of Würzburg), Jochen Seufert (University of Freiburg), Ilpo Huhtaniemi (Imperial College London) & Manuel Tena-Sempere (Universidade de Santiago de Compostela) for ESE, and Representatives of YARE/EYES Group 2013: Annekathrin Keiler, Dresden; Susann Ludwig, Wageningen; Mona Mischke, Wageningen; Raffael Ott, Berlin; Mette Stoedter, Berlin Format & curricular elements: Plenary lectures, Interactive seminars, Workshops, Poster sessions; Sports, Communication & networking activities The beautiful landscape of Bregenz and its surroundings invites for a variety of sports and recreation - swimming, soccer, tennis, skating all around the lake - please don’t forget to bring along your sportswear! ----------------------------------------------------------------------- Sponsors & Support European Society of Endocrinology Deutsche Gesellschaft für Endokrinologie (DGE) Sarcopenia Network FORMOsA DFG Graduiertenkolleg1208 & KFO Charité Berlin EnForCé ----------------------------------------------------------------------- Travel information The most convenient airport is Zurich, Switzerland. Alternatives are the regional airport St. Gallen Altenrhein (via Vienna) or Friedrichshafen. For train connections from the airports please turn to: http://www.sbb.ch/en/http://www.sbb.ch/en/, http://www.bahn.de/, http://fahrplan.oebb.at/http://www.bahn.de/http://fahrplan.oebb.at/ At Bregenz train station you might take the city bus (green line, 1 €), departing every 30 minutes. A walk from the train station to the monastery takes about 15-20 minutes. Scientific Conference Office:Institute of Experimental Endocrinology Charité – University Medicine Berlin Mrs. Elke Abdel-Karim Augustenburger Platz 1 10117 Berlin, Germany Tel.: +49 (0)30-450 524022 E-mail: elke.abdel-karim@charite.deelke.abdel-karim@charite.de Conference Registration:EndoScience Endokrinologie Service GmbH Hopfengartenweg 19 90518 Altdorf Tel.: +49 (0)9187-9742411 E-Mail: info@endoscience.deinfo@endoscience.de Organizer/Veranstalter:Akademie für Fort- und Weiterbildung der DGE Sunday, July 28th - Thursday, August 1st, 2013 Monastery Mehrerau Bregenz, Austria Classical endocrine glands & mesenchymal tissues: Stem Cells, development, function and regulatory principles

2 Provisional Programme (as of April 22, 2013 ) OPENING LECTURE: Jan Åke Gustafsson, USA: Nuclear receptors and metabolism: from lab to drugs IS: Tailoring a receptor ligand for the market DEVELOPMENT OF ENDOCRINE ORGANS AND TISSUES: ADRENAL, MUSCLE AND FAT CELL Ed Laufer, New York, USA: Sonic hedgehog signaling during adrenal development Pierre Val, F: Adrenocortical stem and progenitor cells J. Hofland, NL: Inhibins & activins: their roles in the adrenal gland and the development of adrenocortical tumors THE ART OF TRIMMING PROTEOHORMONES: BIOCHEMISTRY, STRUCTURE, FUNCTION & DISEASES Jens P. Goetze, DK: Prohormone convertases and endocrine disorders IS: Amino- and carboxypeptidases in endocrinology: actions and diseases L. Darryl Quarles, USA: Trimming of osteocyte hormones: The FGF23-Klotho system (IS): NN: Protection of hormone signals: modification by the α-amidating enzyme (PAM) METABOLIC INTERPHASES BETWEEN NUCLEAR RECEPTORS, HORMONES AND CANCER (IS): Gareth Lavery, UK: Metabolism and adrenal cancer (IS): Michela Plateroti, F: TRs, cancer and stem cells ThyroidTransAct SESSION: NOVEL THYROID HORMONE METABOLITES AND ON-CLASSICAL MECHANISMS OF ACTIONS Carolin Höfig, S: Metabolism and actions of TAMs & TACs D. Krautwurst, GER: Structure and function of TAARs L. Appelbaum, IL: Zebrafish as a model for monocarboxyl transporter 8-deficiency ADIPOCYTE DEVELOPMENT, REMODELLING AND SIGNALING Matthias Blüher, GER: WAT: a rich source of endocrine signals Amri Ez-Zoubir, F: BAT, beiging and browning Tim Schulz, USA: BMP7-dependent development and differentiation of BAT ACTIVINS, INHIBINS, & FOLLISTATIN: ENDOCRINE AND PARACRINE ACTIONS OF THE TRANSFORMING GROWTH FACTOR-Β (TGF-Β) SUPERFAMILY LIGANDS Cornel Sieber, GER: Sarcopenia: Clinical features as translational research challenges NN: Hormonal regulation of muscle function and protein metabolism A.U. Trendelenburg; CH: Activin, Inhibin & Follistatin in sarcopenia and osteoporosis NN, Acceleron, USA: Activin antagonists Markus Böhm, GER: Role of Proopiomelanocortin-derived peptides and their receptors in the osteoarticular system: from basic to translational research ENDOCRINE ANIMAL MODELS (IS): E. Wolf, GER: Genetically engineered pig models for translational research Robert Opitz, B: Thyroid development: from stem cell derived funcional tissue to zebrafish models YOUNG INVESTIGATOR’S Sessions (Monday & Thursday) Denise Zwanziger, GER: Aging & Thyroid Axis Laura Mikkonen, FIN: SUMOylation, body weight, adipogenesis & PPARy Andrew Pospisilik, GER: Fat flies & WAT-BAT development NN: Reproductive and metabolic phenotype of a mouse model of PCOS __________________ Blue: confirmed IS: Interactive Seminar Black: invited GENERAL INFORMATION The Bregenz Summer School has a long standing tradition as an interactive hormone and endocrine related brain-storming and meeting place between academia, industry and clinicians. The meeting venue is in a newly renovated complex of beautiful old buildings of the Collegium Bernardi, a boarding school operated by Kloster Mehrerau, within easy walking distance to the shore of the Lake Constance, Bregenz City Park, and a nature preserve. Bregenz, the State Capital of Vorarlberg, is a modern city of 27,000 and is the cultural centre of the province. The Collegium Bernardi can house up to 120 guests, participation will be confirmed on first come - first served basis. Please note that the Summer School is being held during the Bregenz Opera Festival – therefore alternative accommodations may be difficult to obtain. Deadline for registration is July 10, 2013 ! PARTICIPATION FEES Registration Accommodation & board 4 days Senior Scientists € 220.00 + € 300.00 = € 520.00 Students/Postdocs (including accommodation) € 100.00 + € 255.00 = € 355.00 Registration fee for students, postdocs and other participants is including entry to all sessions, welcome reception on Sunday afternoon, coffee breaks and the conference handout. The room and full board package for the entire meeting is 300.00 EUR for senior scientists and 255.00 EUR for students and postdocs. In case of accommodation outside the monastery, meals and coffee breaks at the monastery must be paid cash on site. The accommodation costs include accommodation in a double room with shower/toilet (arrival: July 28, departure: August 1st). We also offer triple-bedrooms. If you want to share your room with (a) certain person(s) who is/are also registered for the conference you can do so via the indicated online-registration link by indicating the name(s). Additional nights have to be paid on your own, they only include breakfast and need to be confirmed by EndoScience GmbH. For Students/Postdocs only: Depending on attracted sponsorship, the registration fee can be refunded upon active participation which requires a poster presentation. Students who will be presenting a poster may apply for reimbursement of the registration fee. In addition, a limited number of travel grants will be available for graduate students/postdocs, depending on incoming support from sponsoring companies/organizations. If only limited money is available, poster-presenting students/postdocs will be preferred. Money refunding and participation will be made available on a “first register and pay, first served” basis. Payment: online http://www.endoscience.de/http://www.endoscience.de/ Registration will be confirmed by mail. If no confirmation is received within one week, please contact the Congress secretariat. Cancellation and refund policy Notification of cancellation must be made in writing until June 30, 2013 and mailed to the congress secretariat with a reference to the bank account where a possible refund may be remitted to. An administrative fee of 30 € will be charged for refunds. Cancellation and refund fee Before July 10, 2013, total refund (excluding the administrative fee). After July 10, 2013 no refunds should be expected. Credit will not be given for unattended events, late arrivals or early departure. All refunds will only be processed after the Meeting. The Bregenz Opera Festival will be presenting Mozart’s “Die Zauberflöte” on the floating stage and “Der Kaufmann von Venedig” by André Tchaikowsky in the Opera house (only on Sunday, July 28) with ticket prices between 30-215 €. There will be tickets available to be booked directly by internet (http://www.bregenzerfestspiele.com/ or telephone: +43 5574 407-6 (ticket centre).http://www.bregenzerfestspiele.com/