1 Innate Immunity: The Immediate Response to InfectionPeter Parham The Immune System Fourth Edition Chapter 2 Innate Immunity: The Immediate Response to Infection Copyright © Garland Science 2015

2 CHAPTER CONTENTS 2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens 2-2 Intracellular and extracellular pathogens require different types of immune response 2-3 Complement is a system of plasma proteins that mark pathogens for destruction 2-4 At the start of an infection, complement activation proceeds by the alternative pathway 2-5 Regulatory proteins determine the extent and site of C3b deposition 2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganismstes

3 CHAPTER CONTENTS 2-7 The terminal complement proteins lyse pathogens by forming membrane pores 2-8 Small peptides released during complement activation induce local inflammation 2-9 Several classes of plasma protein limit the spread of infection 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

4 Innate Immunity: the Immediate Response to Infection2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

5 2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

6 Innate Immunity: the Immediate Response to Infection2-2 Intracellular and extracellular pathogens require different types of immune response

7 2-2 Intracellular and extracellular pathogens require different types of immune response

8 Innate Immunity: the Immediate Response to Infection2-3 Complement is a system of plasma proteins that mark pathogens for destruction

9 2-3 Complement is a system of plasma proteins that mark pathogens for destruction

10 2-3 Complement is a system of plasma proteins that mark pathogens for destruction

11 2-3 Complement is a system of plasma proteins that mark pathogens for destruction

12 Innate Immunity: the Immediate Response to Infection2-4 At the start of an infection, complement activation proceeds by the alternative pathway

13 2-4 At the start of an infection, complement activation proceeds by the alternative pathway

14 2-4 At the start of an infection, complement activation proceeds by the alternative pathway

15 2-4 At the start of an infection, complement activation proceeds by the alternative pathway

16 Innate Immunity: the Immediate Response to Infection2-5 Regulatory proteins determine the extent and site of C3b deposition

17 2-5 Regulatory proteins determine the extent and site of C3b deposition

18 Innate Immunity: the Immediate Response to Infection2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

19 2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

20 Innate Immunity: the Immediate Response to Infection2-7 The terminal complement proteins lyse pathogens by forming membrane pores

21 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

22 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

23 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

24 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

25 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

26 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

27 Innate Immunity: the Immediate Response to Infection2-8 Small peptides released during complement activation induce local inflammation

28 2-8 Small peptides released during complement activation induce local inflammation

29 Innate Immunity: the Immediate Response to Infection2-9 Several classes of plasma protein limit the spread of infection

30 2-9 Several classes of plasma protein limit the spread of infection

31 Innate Immunity: the Immediate Response to Infection2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

32 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

33 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

34 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

35 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

36 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

37 Innate Immunity: the Immediate Response to Infection2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

38 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes