1 Metabolism and the Gut-liver Axis in Non-Alcoholic Fatty Liver DiseaseH2020-MSCA-ITN-2016 Metabolism and the Gut-liver Axis in Non-Alcoholic Fatty Liver Disease ETN - Acronym: “FOIE GRAS” Budget: ,68 € Prof fizjologii zwierzat, Biore aktywny udzial w grupach eksperckich dla programow takich jak MSCA, IDEAS i dla projektow pla poszczegolnych panst w europejskich tj. Wellcome Trust ,Ministerstwo Nauki w….. Obecny jest to 3 projekt europejski, ktory koordynuje. Pierwszy, w roku 2008 w Italii (ERC IDEAS), drugi, z 7 programu ramowego (lacznie 3 miliony euro) w IGHZ i ten 3 tez w IGHZ. udzial kobiet w koordynacji projektow europejskich, rowniez w Polsce jest bardzo niewielki. Koordynacja kobiety pociaga za soba «zwiekszenie ilosci «koordyntorow» danego projektu Coordinator: Paulo Oliviera University of Coimbra

2 ITN Project – Participants“FOIE GRAS” ITN Project – Participants PORTUGAL PORTUGAL PORTUGAL POLAND Center for Neuroscience and Cell Biology in Coimbra- Faculty of Pharmacy of the University of Lisbon University of Porto Nencki Institute of Experimental Biology, PAS, Warsaw Paulo Oliviera Cecília Rodrigues António Ascensão Mariusz Wieckowski

3 ITN Project – Participants“FOIE GRAS” ITN Project – Participants ITALY ITALY GERMANY Italian National Research Council (CNR) University of Bari Medical School Helmholtz Zentrum München - German Research Center for Enviromental Health Amalia Gastaldelli Piero Portincasa Hans Zischka

4 ITN Project – Participants“FOIE GRAS” ITN Project – Participants FRANCE SPAIN CZECH REPUBLIC French National Health and Medical Research Institute (INSERM) Institute of Biomedical Research of Barcelona Institute of Physiology of Czech Academy of Sciences Joan Roselló Catafau Carina Prip-Buus Jan Kopecky

5 ITN Project – Partners Organisations“FOIE GRAS” ITN Project – Partners Organisations GERMANY GERMANY PORTUGAL DENMARK Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH CETICS Healthcare Technologies GmbH APDP – Diabetes Portugal Seahorse Bioscience Europe Aps

6 Metabolism and the Gut-liver Axis in Non-Alcoholic Fatty Liver DiseaseNon-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable. Untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment.

7 FOIE GRAS provides innovative training for 13 early stage researchers (ESRs)1) to identify mechanisms and consequences of metabolic remodelling secondary to mitochondrial alterations during NAFLD 2) to identify related circulating biomarkers that will underpin better diagnostic tests for NAFLD to answer critical and unanswered questions:

8 Non-invasive Profiling of Mitochondrial Function H2020-MSCA-RISE-2016 Title of the Project Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease Acronym: “mtFOIE GRAS” Budget: ,00 € Prof fizjologii zwierzat, Biore aktywny udzial w grupach eksperckich dla programow takich jak MSCA, IDEAS i dla projektow pla poszczegolnych panst w europejskich tj. Wellcome Trust ,Ministerstwo Nauki w….. Obecny jest to 3 projekt europejski, ktory koordynuje. Pierwszy, w roku 2008 w Italii (ERC IDEAS), drugi, z 7 programu ramowego (lacznie 3 miliony euro) w IGHZ i ten 3 tez w IGHZ. udzial kobiet w koordynacji projektow europejskich, rowniez w Polsce jest bardzo niewielki. Koordynacja kobiety pociaga za soba «zwiekszenie ilosci «koordyntorow» danego projektu Coordinator: Paulo Oliviera University of Coimbra

9 RISE Project – Participants“mtFOIE GRAS” RISE Project – Participants PORTUGAL PORTUGAL PORTUGAL Center for Neuroscience and Cell Biology in Coimbra- Faculty of Pharmacy of the University of Lisbon University of Porto Paulo Oliviera Cecília Rodrigues António Ascensão

10 RISE Project – Participants“mtFOIE GRAS” RISE Project – Participants POLAND ITALY ITALY Nencki Institute of Experimental Biology, PAS, Warsaw Italian National Research Council (CNR) University of Bari Medical School Mariusz Wieckowski Amalia Gastaldelli Piero Portincasa

11 RISE Project – Participants“mtFOIE GRAS” RISE Project – Participants GERMANY SPAIN UNITED KINGDOM Helmholtz Zentrum München - German Research Center for Enviromental Health Institute of Biomedical Research of Barcelona KING'S COLLEGE LONDON Hans Zischka Joan Roselló Catafau Afshan Malic

12 RISE Project – Partners Organisations“mtFOIE GRAS” RISE Project – Partners Organisations GERMANY GERMANY PORTUGAL AUSTRIA Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH CETICS Healthcare Technologies GmbH APDP – Diabetes Portugal OROBOROS INSTRUMENTS GmbH

13 H2020-MSCA-RISE-2016 “mtFOIE GRAS”mtFOIE GRAS will integrate a diversity of on-going NAFLD projects intersecting basic research, clinical implementation, technology development and transfer, as well as social outreach, under a common goal. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment Prof fizjologii zwierzat, Biore aktywny udzial w grupach eksperckich dla programow takich jak MSCA, IDEAS i dla projektow pla poszczegolnych panst w europejskich tj. Wellcome Trust ,Ministerstwo Nauki w….. Obecny jest to 3 projekt europejski, ktory koordynuje. Pierwszy, w roku 2008 w Italii (ERC IDEAS), drugi, z 7 programu ramowego (lacznie 3 miliony euro) w IGHZ i ten 3 tez w IGHZ. udzial kobiet w koordynacji projektow europejskich, rowniez w Polsce jest bardzo niewielki. Koordynacja kobiety pociaga za soba «zwiekszenie ilosci «koordyntorow» danego projektu mtFOIE GRAS will create an inter-sectorial network to encourage synergies between the partners, along academic and industrial research, The main scientific goal of mtFOIE GRAS is to identify innovative biomarkers and develop non-invasive methodologies for mitochondrial profiling in the context of NAFLD/NASH.

14 Metabolism and the Gut-liver Axis in Non-Alcoholic Fatty Liver DiseaseH2020-MSCA-ITN-2016 Metabolism and the Gut-liver Axis in Non-Alcoholic Fatty Liver Disease ETN - Acronym: “FOIE GRAS” Prof fizjologii zwierzat, Biore aktywny udzial w grupach eksperckich dla programow takich jak MSCA, IDEAS i dla projektow pla poszczegolnych panst w europejskich tj. Wellcome Trust ,Ministerstwo Nauki w….. Obecny jest to 3 projekt europejski, ktory koordynuje. Pierwszy, w roku 2008 w Italii (ERC IDEAS), drugi, z 7 programu ramowego (lacznie 3 miliony euro) w IGHZ i ten 3 tez w IGHZ. udzial kobiet w koordynacji projektow europejskich, rowniez w Polsce jest bardzo niewielki. Koordynacja kobiety pociaga za soba «zwiekszenie ilosci «koordyntorow» danego projektu H2020-MSCA-RISE-2016 Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease Acronym: “mtFOIE GRAS”