1 Clinical research into Chinese herbal medicine at the University of Southampton, UKProf George Lewith Dr Andrew Flower Dr Lily Lai Dr Hu Xiao Yang Martin Logue MSc

2 Research aims To evaluate the existing evidence base for Chinese herbal medicine (CHM) using systematic reviews and evidence synthesis To explore ways of defining best practice in CHM using Delphi, Nominal Group Technique, and the Five Phases Model. To develop novel rigorous mixed methods methodologies to test the effectiveness of CHM, with a particular focus on treatments for anti-microbial resistance. To pilot these methodologies and investigate the feasibility of running clinical trials within a Western primary care setting To conduct larger definitive trials of CHM for use within primary care.

3 Systematic reviews to support clinical researchCochrane reviews: CHM for endometriosis Cochrane Database of Systematic Reviews, Issue 5. Art. No.: CD006568 CHM for recurrent urinary tract infections Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD010446 Systematic reviews: CHM for polycystic ovarian syndrome (PCOS) Andrographis paniculata (Chuan Xin Lian) for acute respiratory tract infection European Journal of Integrative Medicine :8:2-3 September 2016

4 Clinical trials investigating CHMA randomised, double blind, placebo controlled feasibility study to explore the role of CHM decoctions for endometriosis. J. Alt & Comp Med. 2011;17: Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK. BMJ Open 2017;7 :e A randomised, double blind placebo controlled feasibility study comparing individualised and standardised CHM for recurrent urinary tract infections (in progress) Trials. 2016;17:358.

5 CHM Clinical trials (pending)Standardised Chinese Herbal Medicine for Oligomenorrhoea and Amenorrhoea in Polycystic Ovary Syndrome: a Prospective Observational Study Andrographis paniculata as a Symptomatic Intervention for Acute Respiratory Tract Infections: a double blind RCT.

6 Southampton University-a leading centre for herbal medicine researchContact: Andrew Flower