The New Science on Food as Medicine: Research and Protocols

1 The New Science on Food as Medicine: Research and Proto...

Author: Jacob Logan

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1 The New Science on Food as Medicine: Research and ProtocolsGood Morning …. Your great …. We highly respect your difficult and arduous task of getting people well today. Its an honor to present to you The Intelligence and Power of therapeutic Food Supplements: Research and Protocols. Food is only as good as the soil it is grown in and the farming practices used. This is a permaculture sithe. © BioImmersion, Inc., 2017 All Rights Reserved.

2 Intelligence and Power of Therapeutic FoodsThe power of food is found in its historicity and research. Research on foods as a therapeutic tool is definitive and encouraging. Learning how to utilize foods to heal the difficult ailing conditions of our time is imperative. Food in concentrated form is foundational to your protocols. BioImmersion exercises its Forward Thinking modality in the way they work with scientists, eco-farmers and physicians from all over the world to form an exciting range of potent Therapeutic Foods. © BioImmersion, Inc., All Rights Reserved.

4 © BioImmersion, Inc., 2017. All Rights Reserved.“Food as Medicine” In Pub Med from 1899 to the present, 120,227 research papers were published using the term food as medicine. In the first three decades there were only 13 articles sited. Example: Arnold L. (1912). Influence of food upon the bacterial flora of the small intestine. Am J of Pub Health, 17(9), From scientific findings to a Therapeutic Food: Therapeutic Foods with prebiotics (fiber), probiotics, their metabolites (supernatant), and ORNs. © BioImmersion, Inc., All Rights Reserved.

5 A Rising Tide of Research on Food as Medicine1927 to more papers on the topic. 1950 to addition papers. 1960 to an exponential growth. 1965 to the present- 118,661 more! Example: Serein et al. (2016). Cardiovascular benefits from ancient grain bread consumption: findings from a double-blinded randomized crossover Intervention trail. Int J Food Sci Nutr, 9, 1-7. From scientific findings to a Therapeutic Food: Be Regular. Ancient seeds and one grain, organic and gluten free. © BioImmersion, Inc., All Rights Reserved.

6 Serein et al., (2016), Conclusion for Cardiovascular Health45 clinically healthy subjects were included in a randomized, double-blinded crossover trial aimed at evaluating the effect of a replacement diet with bread derived from ancient grain varieties versus modern grain varieties on cardiovascular risk profiles. After 8 weeks of intervention, consumption of bread obtained by the ancient varieties shown to result in a significant amelioration of various cardiovascular parameters. Showed a significant reduction in total cholesterol, low-density LDL, and blood glucose. Whereas no significant difference during the phase with the modern variety were reported. Moreover a significant increase in circulating endothelial progenitor cells were reported after the consumption of product made for the ancient variety. © BioImmersion, Inc., All Rights Reserved.

7 Food Science: Research, Findings, ProtocolsCancer Support Cardiovascular Support Cold and Flu Support Detoxification Gastrointestinal Support Healthy Aging Support Inflammatory Support Metabolic Support Neurological Support Osteoskeletal Support Urogenital Support Weight Loss Support Each of these categories has immense amount of scientific research that demonstrate how food is used to prevent, repair, and maintain our health. We design our therapeutic foods formulas according to the scientific findings. Our philosophy is simple, we teach the Harvard Medical School (including WHO and Kaiser Permante, NIH, Mayo Clinic) basic plant-based diet program that includes a little fish. We suggest a 90% plant based and 10% meat/eggs/dairy. © BioImmersion, Inc., All Rights Reserved.

8 Food Science and Cancer Support“The American Institute for Cancer Research has their Ten Recommendations for Cancer Prevention and most of them center around the food choices we make.” © BioImmersion, Inc., All Rights Reserved.

10 © BioImmersion, Inc., 2017. All Rights Reserved.Daily Regime Garlic, organic- 1 to 2 capsules daily Cruciferous Sprout Complex- 3 to 4 capsules daily, preferably on empty stomach Phyto Power, wild crafted- 1 to 2 caps daily Beta Glucan High Potency Synbiotic- 2 tbl daily © BioImmersion, Inc., All Rights Reserved.

11 © BioImmersion, Inc., 2017 All Rights Reserved.Boivin et al. (2009). Antiproliferative and antioxidant activities of common vegetables: A comparative Study. Food Chemistry; 112(20): The researchers evaluated the inhibitory effects of extracts isolated from 34 vegetables on the proliferation of 8 different tumor cell lines: breast cancer, brain tumors, kidney cancer, lung cancer, childhood brain tumors, pancreatic cancer, prostate cancer and stomach cancer. The best by far were vegetables from the Allium and Cruciferous families- inhibiting 100% of these cancers. Epidemiological studies have consistently linked abundant consumption of fruits and vegetables to a reduction of the risk of developing several types of cancer. A large number of population-based studies have consistently shown that individuals who eat five servings or more of fruits and vegetables daily have approximately half the risk of developing a wide variety of cancer types, particularly those of the gastrointestinal tract © BioImmersion, Inc., 2017 All Rights Reserved.

20 Boivin et al., (2009): conclusionThe inclusion of cruciferous and allium vegetables in the diet is essential for effective dietary based chemo preventative strategies. Specifically what phytonutrients are involved within the garlic and cruciferous families. What about Phyto Power and Beta Glucan High Potency Synbiotic and their anti-cancer phytochemicals? © BioImmersion, Inc., All Rights Reserved.

22 © BioImmersion, Inc., 2017. All Rights Reserved.Food Science on Garlic Cao et al. (2014). Garlic-derived allyl sulfides in cancer therapy. Anticancer Agents Med Chem, 14(6), Romagnolo, D.F., Davis, C.D., Milner, J.A. (2012). Phytoalexins in cancer prevention. Front Biosci (Landmark Ed), 17, Nepravishta et al. (2012). Oxidative species and s-glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. FEBS J, 279(1), Melino, S., Sabelli, R., Paci, M. (2011). Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy. Amino Acids, 41(1), Key Words: Cao: Garlic-derived allyl sulfides- these are the activated metabolites from the alliin + Alliinase reaction. Romagnolo: Phytozlexins in cancer prevention- What are phytoalexins? They are another name for the Allyl sulfides. These are the active metabolites. Nepravishta: apoptosis induced by allyl thiosulfates. Again Allyl sulfides are synonymous with allyl thiosulfates. Melino: cellular detoxification systeme? How do the allyl sulfur compounds help here. What does this mean? © BioImmersion, Inc., All Rights Reserved.

24 Food Science on Cruciferous VegetablesAbdull Razis, A.F., & Noor, N.M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pac J Cancer Prev, 14(3), Steinkellner et al. (2001). Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, , © BioImmersion, Inc., All Rights Reserved.

25 The Comet Test on Garlic and BerriesKurzawa-Zegota et al. (2012). The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food Chem Toxicol, 50(2), The food mutagens IQ (2-amino-1-3-methylimidazo quinoline) and PhIP (2-amino-1methyl-6-phenylimidazo pyridine) are heterocyclic amines, generated when heating proteinaceous food. This study investigates the protective potential of the flavonoids against oxidative stress induce DNA damage in lymphocytes from healthy individuals and untreated, newly diagnose colon cancer patients using the Comet assay. © BioImmersion, Inc., All Rights Reserved.

31 © BioImmersion, Inc., 2017. All Rights Reserved.Seeram, N.P. (2008). Berry fruits for cancer: current status and future prospects. J Agric Food Chem, 56(3), Their anticancer potential benefits are related to their polyphenols (flavonoids, proanthocyanidins, gallotannis, phenolic acids), stilbenoids, lignans and triterpennoids The benefits of berries: (1) Counteract, reduce and repair damage from oxidative stress and inflammation; (2) Regulating carcinogen and xenobiotic metabolizing enzymes, transcription and growth factors, inflammatory cytokines, and cellular signaling pathways that lead to treatment resistance; (3) Sensitize tumor cells to chemotherapeutic agents by inhibiting pathways that lead to treatment resistance; (4) Provide protection from therapy-associated toxicities. © BioImmersion, Inc., All Rights Reserved.

35 PubMed Papers on FlavonoidsAs we look at Flavonoids in terms of volumes on scientific papers on their value towards our health in 2013 there were 65,531 and as I sited in our earlier slide there were in 2016 in PubMed 87,776. © BioImmersion, Inc., All Rights Reserved.

36 Going Beyond Isolated Vitamins & MineralsVitamins, Mineral, Amino Acids, Fiber, etc. and the other phytonutrients. What about Vitamin P, Q, and U? What about the Microbiome and health? As of October 16, 2016 there were 87,776 reviewed studies on Flavonoids in PubMed. Of course, there has been accepted in main stream medicine the importance of Macro nutrient and Micro nutrients vitamins and minerals but phytonutrients and probiotics were not considered seriously. In fact they down graded Vitamin P, Q and U to secondary metabolites. © BioImmersion, Inc., All Rights Reserved.

37 Lack of Secondary Metabolites and NCDs“Secondary metabolites are organic compounds that are not directly involved in normal growth, development, or reproduction of an organism. Unlike primary metabolites, absence of secondary metabolites does not result in immediate death, but rather long-term impairment of the organism’s survivability and fecundity.” Franenkel, G.S. (1959). The raison d’Etre of secondary plant substances. Science; 129(3361): The Seminal paper on defining secondary metabolites was presented in Science (1959) The raison d’Etre of secondary plant substances. Secondary metabolites are organic compounds that are not directly involved in normal growth, development, or reproduction of an organism. Unlike primary metabolites, absence of secondary metabolites does not result in immediate death, but rather long-term impairment of the organism’s survivability and fecundity Absence of secondary metabolites does not result in immediate death, but rather long-term impairment of the organism’s survivability and fecundity. Sound like exactly what we are dealing with today. It is predicted that our present newest generation will not have the life expectancy of the previous generations. It is predict that our present generation will not have the life expectancy of the previous generation. . © BioImmersion, Inc., All Rights Reserved.

38 The Hormetic Effects of Phyto ChemicalsSmall amounts have profound effects on our body Hormone like action. Metabolic performance Amplification of cell signaling pathways A few high active berries go a long way © BioImmersion, Inc., All Rights Reserved.

39 Proposed Polyphenol ActionsAntioxidant activity: scavenge free radicals and reduce oxidative stress. Antimicrobial and antiviral effects. Inhibition of cell proliferation/ induction of cell-cycle arrest. Regulation of steroid hormone (esp. estrogen) metabolism. Inhibition/activation of signal transduction pathways. Induction of cell differentiation. Inhibition of oncogene expression © BioImmersion, Inc., All Rights Reserved.

40 © BioImmersion, Inc., 2017. All Rights Reserved.Induction of tumor suppressor gene expression Induction of apoptosis Enzyme induction and enhancement of detoxification Phase II enzyme: glutathione peroxidase; catalase; superoxide dimutase. Enzyme inhibition Phase I enzyme (blocks activation of carcinogens); cyclooxygenase-2: inducible nitric oxide synthase; xanthine oxidase Enhancement of immune functions and surveillance Inhibition of cell adhesion, invasion and angiogenesis Inhibition of nitrosation and nitration Prevention of DNA binding and damage © BioImmersion, Inc., All Rights Reserved.

51 © BioImmersion, Inc., 2017. All Rights Reserved.Moli et al. (2007). P53 and Nur77/TR3- transcription factors that directly target mitochondria for cell death induction. Oncogene; 25, Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. phytonutrients such as allicin, apigenin, berberine, butein, caffeic acid, capsaicin, catechin gallate, celastrol, curcumin, epigallocatechin gallate, fisetin, flavopiridol, gambogic acid, genistein, plumbagin, quercetin, resveratrol, sanguinarine, silibinin, sulforaphane, taxol, y-tocotrienol, and zerumbone, can modulate inflammatory pathways and thus affect the survival proliferation ,invasion, angiogenesis, and metastasis of the tumor. We now know that as many as 35% of all cancers can be prevented by dietary change. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. The pathways associated with this process have been linked to chronic inflammation, a major mediator of tumor progression. The human body consists of 13 trillion cells, almost all of which are turned over within 100 days, indicating that 70,000 cells undergo apoptosis every minute. Thus, apoptosis/cell death is a normal physiological process, and it is rare that a lack of apoptosis kills the patient. Almost 90% of all deaths due to cancer are linked to metastasis of the tumor. © BioImmersion, Inc., All Rights Reserved.

53 The Beta Glucan Synbiotic provides pedigreed lactic acid bacteriaThey are fermenting bacteria, not putrefying bacteria and they put an inhibitory pressure on the growth of the putrefying strains. These organisms produce copious amounts of butyrate which facilitates the tightening of the colonic epithelium. The probiotics reduce and bind heterocyclic amines and nitrosamines – well established in research as carcinogenic molecules. One hot dog has as many nitrosamines as five cigarettes. They are found in unprocessed meat as well: beef, chicken, and pork. These strains support the detoxification of heavy metals. © BioImmersion, Inc., All Rights Reserved.

54 The effects of ß glucans on cancer metastasis. Yoon, Y.J., Koppuls, D., Lee K.H. (2013). Anticancer Agents Med Chem; 13(5): Beta-glucans, naturally occurring polysachcharides, are present as constituents of the cell wall of cereal grains, muchrooms, algae, or microbes including bacteria, fungi, and yeast. Researchers have well established the significant role of Beta glucans on the immune system relative to cancer treatment, infection, immunity, and restorative of damaged bone marrow. As an immunomodulating agent, Beta glucan acts through the activation of innate immune cells such as macrophages, dendritic cells, granulocytes, and natural killer cells. This activation triggers the responses of adaptive immune cells resulting in the inhibition of tumor growth and metastasis. © BioImmersion, Inc., All Rights Reserved.

55 Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Cani et al. (2009). Gut; 58(8): On excessive high-fat feeding, intestinal microflora changes. This is associated with an increased intestinal permeability. Consequently, endotoxemia increases and triggers inflammation and metabolic disorders. © BioImmersion, Inc., All Rights Reserved.

The New Science on Food as Medicine: Research and Protocols

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